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Alternative Treatment to Steroids for Mesangial Proliferative Glomerulonephritis

Alternative Treatment to Steroids for Mesangial Proliferative GlomerulonephritisMesangial proliferative glomerulonephritis (MsPGN) usually presents proteinuria, hematuria, Nephrotic Syndrome and so on. To inhibit inflammatory reactions within glomerular mesangial area, steroids are often taken but may fail to work. In this case, patients have to seek alternative treatment to steroids for their MsPGN.

What is mesangial proliferative glomerulonephritis?

According to immune pathogenesis, MsPGN can be divided into two types: IgA Nephropathy and MsPNG without IgA deposits. Most cases of this disease burst after infections, particularly upper respiratory infection. In clinic, MsPGN may present the form of Nephrotic Syndrome or Nephritis Syndrome, and patients have typical proteinuria.

Steroids for patients with mesangial proliferative glomerulonephritis

Through inhibiting the inflammation within kidney filters and preventing protein from leaking, steroids can help relieve patients’ proteinuria and slow down the progress of kidney disease. However, if high blood pressure is involved in MsPGN or patients’ kidney disease is quite serious, they are more likely to not respond to steroids. This means some other treatments are needed.

Alternative treatment to steroids for MsPGN patients

If patients have high blood pressure, the first thing should be to manage their blood pressure. ACEI and ARBs are often taken to lower MsPGN patients’ high blood pressure. If your blood pressure can’t be reduced by these medicines, try to alter your medicines with doctor’s advice.

The next step is to take one systemic treatment, called Immunotherapy. With closely linked six steps, Immunotherapy can not only eliminate the deposits of immune complexes like IgA from kidney filters but also repair damaged kidney cells and protect the remaining kidney function. As long as the pathogenic factors are excreted out, mesangial proliferative glomerulonephritis will be treated fundamentally.

This is one general introduction for MsPGN treatment. If you want to know more about these treatments, you can leave a message to We are glad to share information for you.

  • Tag: Nephritis Treatment Nephritis Nephritis Immunotherapy
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