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How Does FSGS Appear And Develop

How Does FSGS Appear And DevelopFSGS is a kidney disease that is more likely to appear in young people, and it often cause patient to have nephrotic syndrome. FSGS will progress slowly, and it can cause kidney failure in the end. What is the medical pathogenesis of FSGS?

What are the causes of FSGS?

FSGS can be divided into the primary and the secondary.

For patient who has primary FSGS, gene mutation may be a major cause, while familial inheritance may also be a reason of FSGS.

Secondary FSGS means FSGS is caused by other factors, like virus, medicines, etc. Besides, it can also be caused by the shortage of blood and oxygen in kidney, which can be caused by many reasons, like hypertension, renal artery stenosis, cholesterol crystal embolism, etc.

What factors can influence the appearance of FSGS?

Many factors can influence the appearance of FSGS, but FSGS can be influenced more obviously by some factors.

Hereditary background:the morbidity of FSGS in different races has obvious difference, and it has high morbidity in Afro-America, which indicates genetic background makes an important influence in the appearance of FSGS.

TteRRF: TteRRF also makes a significant influence in the appearance of FSGS. Kidney transplant has a bad effect in patient with FSGS, because patient who accepts kidney transplant can have proteinuria in 24 hours after surgery. While if proteinuria has not been relieved in several months, patient’s kidney can be found having FSGS lesion.

How does FSGS develop?

The pathogenetic factor can stimulate the inherent cells of glomerulus, which can lead to the increase of extracellular matrix’s excretion and the effusion of blood plasma. That can damage the blood vessel, which will lead to the formation of sclerosis, and these factors will also expand the lesion area, which cause its aggravation. Besides, some other external factors can also promote the development of FSGS, like tiredness, hypertension, too much sodium intake, etc.

In the end, if you have any problem in dealing with this disease, you can just email us about your question, and we will give you a detailed reply in time.

  • Tag: FSGS Basics
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