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FSGS: Symptoms, Causes, Treatment

FSGS: Symptoms, Causes, TreatmentFocal segmental glomerulosclerosis (FSGS) is a primary glomerular disease. It progresses gradually, and often causes nephrotic syndrome. Patients with FSGS will have kidney failure eventually.


Nephrotic syndrome and proteinuria are the most obvious presentation of FSGS, and patient with FSGS mainly suffers from the symptoms of nephrotic syndrome.

Foamy urine: as we know, foamy urine is a major symptom in patient with proteinuria, and patient will see small foams on his urine surface for a long time.

Edema: patient with FSGS can have obvious edema, which is also caused by proteinuria. Edema will appear from patient’s ankles at the beginning, while for patient with severe condition, he may have edema in his abdomen or lungs.

Hypertension: this is a symptom that can be noticed easily in FSGS patient, which mainly presents as mild and persistent hypertension.

Blood urine: FSGS patients may find they have blood in their urine, but it is more likely to appear as microscopic blood urine.


Genetic factors: different races have obvious difference in the incidence of GSGS, and it is more likely to occur in black people of America, which indicates it has close relation with genetic factors.

TteRRF: FSGS patients who have accept kidney transplant will have relapse rapidly, which means TteRRF exists.

Other factors: FSGS can be caused by many factors, such as toxins, humoral immunity, hemodynamic changes, etc. These factors can cause damage in capillary wall, which can cause the formation and retention of big molecule protein, and that may damage glomeruli eventually.


FSGS is a disease that can progress slowly and gradually. In fact, there is not a therapy that can cure this disease, but with right treatment, patient’s condition can be well controlled and his life will also be effectively prolonged.a

Hypertension and proteinuria should be treated. Hypertension is common in patient with FSGS, and it can aggravate patient’s kidney damage obviously if it has not been well controlled, so does proteinuria. In treating hypertension, some effective medicines like ACEI and ARB may be used to control patient’s blood pressure. In the treatment of proteinuria, patient will need to have strict restriction in their protein intake, which is a great help in treating this symptom.

Besides, patient should do their best to preserve and improve his kidney function. In fact, most nephrons in patient’s kidney are just damaged, which are able to be improved if patient accept right treatment, and that will be a great help in prolonging patient’s lifetime. While some therapies are good at this aspect, like micro-Chinese medicine osmotherapy, immunotherapy, etc.

These are the basic aspects of FSGS, and if you have any problem in dealing with disease, you can contact us, and we are willing to help you.

  • Tag: FSGS Basics
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