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Signs of Stage 4 CKD: Fatigue, Itching and Muscle Tightness

Signs of Stage 4 CKD: Fatigue, Itching and Muscle TightnessStage 4 Chronic Kidney Disease is characterized by severe reduction in kidney function. People with this disorder have glomerular filtration rate (GFR) at 15-29 ml/min, which means the kidneys are working at least 70% less efficiently. Symptoms like fatigue, itching, and muscle tightness can be associated with Stage 4 CKD. You can chat with our online doctor directly for free and personalized advice!


Patients have feelings of constant tiredness, drowsiness, and lethargy. Causes for this symptoms are:

1) Anemia. Healthy kidneys make a hormone called EPO, that tells the body to make oxygen-carrying red blood cells. As the kidneys are severely damaged, they make less EPO. With fewer red blood cells to carry oxygen, patients' muscles and brain tire very quickly; 2) Drugs or medications such as some antidepressants, antihypertensives, steroids, and anti-anxiety drugs. 3) Hypoglycemia. Abnormally low blood sugar level is often related with chronic fatigue.


It is a very common symptoms of Stage 4 CKD. Itching can occur over the whole body, it is often worse at night, and can be relentless. Itchy skin occurs due to the accumulation of toxic wastes in the blood, finally finding their way to the skin. Particularly, itchy skin is the symptom of excessive phosphate in the blood stream.

Muscle tightness

Muscle tightness can be very painful, resulting in discomfort and the inability to perform daily tasks. There can be many causes to this symptom including certain medications, physical inactivity, emotional tension (anxiety, worry, anger, sad, etc), and improper mineral levels (magnesium, calcium, potassium).

Treatment for Stage 4 CKD symptoms like fatigue, itching, and muscle tightness depends upon the cause. It may involve use of proper medications and nutritional supplements, dietary alterations and lifestyle changes. If you would like to know more details about natural remedies to relieve these discomforts, feel free to leave a message in the below or email us at

  • Tag: CKD symptoms
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