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Why Do Stage 4 Kidney Failure Patients Lose Their Appetite

Why Do Stage 4 Kidney Failure Patients Lose Their AppetiteFor patients with stage 4 kidney failure, many systems can appear in their body, among which loss of appetite is also very common.

Loss of appetite can cause bad influence to patient’s diet, which can make bad influence to patient’s overall health condition.

While, why do patients with stage 4 kidney failure have this problem?


For patient with stage 4 kidney failure, their disease can cause many metabolic disorders in their body, and the secretion of leptin will be increased. While leptin can inhibit hypothalamus excreting neuropeptide Y, which can affect patient’s appetite, and cause loss of appetite.


Patients with stage 4 kidney failure often have edema in their body, which can be caused by massive proteinuria or low kidney function. And some patients can even have edema in their gastrointestinal system, which can also cause patient to have loss of appetite.

3.The accumulation of wastes:

Due to patient’s poor kidney function, there will be lots of wastes accumulating in patient’s body. Some toxins, like urea and creatinine, can stimulate the bacteria in patient’s intestinal tract, and make them to decompose the metabolic wastes and produce toxic gas, which can stimulate patient’s digestive system and cause loss of appetite.

4.Nerve problem:

As the accumulation of toxins and metabolic wastes, they will damage patient’s nerve system, which can cause problems in there.

In fact, patient with stage 4 kidney failure can have nerve problems like loss of appetite, descending in concentration, memory and understanding, etc.

Thereby, many factors can cause patient to have loss of appetite, and to solve this problem, patient should find its real causes, and then measures can be taken more effectively.

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