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Is Tolvaptan Help Polycystic Kidney Disease

Posted: by Jobeth      Time: 2013-03-13 17:04

Topics: PKD

Details: Hello, I want to ask about the new medicine for PKD named " Tolvaptan". Is that Real helpful in PKD, and is that available in the market already? Thank you.

Expert Answer
Thank you for your inquiry. And I learn about that you want to know the information about the' TOLVAPTAN'. And know some about this medicine as follow. Hope it can help you more or less .

A vasopressin V2 receptor antagonist (the nonpeptide AVP2 receptor antagonist), the concentration of sodium ions in the plasma can be elevated and excess water from urine. Enhance the ability of the kidneys to process water. Polycystic kidney accumulation of intracellular cyclic adenosine monophosphate (cAMP), promote cyst growth by stimulating the secretion of cyst fluid and lining cell hyperplasia. The tolvaptan Is type 2 vasopressin receptor antagonists inhibit cAMP generation and accumulation. In PKD animal model study, tolvaptan showed good efficacy.

Yes it is available in the market .

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