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What Causes a Bad Prognosis of IgA Nephropathy

It is hard to find a standard answer for the prognosis of IgA Nephropathy, because it differs from person to person. Someone may live with IgA Nephropathy for more than 20~30 years while some others may develop into kidney failure within 2 years. Good news is some causes of a bad prognosis of IgA Nephropathy is clear for us. This will help your doctor to make a better plan to prevent the poor outcome of this disease.

Gross Proteinuria

According to a research established in Japan, the patient who has gross proteinuria under control can delay the Kidney Failure stage as longest as 30 years. However, if you suffer from persistent protein in urine of more than 0.4grams per day, your kidney function decline will worse than average speed for may actually itself cause further damage to the nephrons.

High blood pressure

High blood pressure is the very common symptoms of Kidney Disease. For many patient, it is hard to control the blood pressure in a stable level below 125/75. Even though you cannot achieve the target blood pressure, lower is better. You are suggested to take medicine and special diet to keep your blood pressure under control.


Glomeruloscleroisis refers to the scarring of the glomeruli caused by the deposition of IgA in kidney tissues. The glomerulosclerosis is also an indicator of poor prognosis of IgA Nephropathy in clinic. If the average sclerosis per glomerulus is less than 10%, there might be a chance it won't progress very fast or maybe at all with the right treatment (especially the right blood pressure medications).

High Creatinine Level

Creatinine level indicates the kidney function levels. If creatinine levels elevates, it means at least 50% of kidney function has been lost. If untreated, kidney function decline will continue gradually. Somewhere between2.2 to 3.5 mg/dl, there is a point of no return after which it is likely that end-stage will be reached eventually.

Even with all the indicators for a poor prognosis, it might take years or even decades until the person reaches end stage. Thereby, you are suggested to take right lifestyle and treatment as soon as possible and make the greatest of the time to prevent Kidney Failure and ESRD. More information, you can contact: .

  • Tag: IgA Nephropathy Basics
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