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Does Everyone With Iga Nephropathy Have ESRD

Does Everyone With Iga Nephropathy Have ESRD  IgA nephropathy is a disease that often cause patient to have nephrotic syndrome, which can aggravate patient’s kidney damage obviously, while does everyone’s IgA nephropathy will progress into end stage renal disease (ESRD)?

What is the pathogenesis of IgA nephropathy?

IgA nephropathy is called because it is caused by the accumulation of immune complexes of IgA immunoglobulin in patient’s kidney, especially the accumulation in patient’s glomerular mesangial area.

The accumulation of immune complexes in kidney can cause inflammatory reaction in there, and when they can not be removed by immune system, that will cause IgA nephropathy.

Besides, IgA nephropathy often causes patient to have nephrotic syndrome, which means patient will have obvious edema and massive proteinuria. While that is because when immune complexes accumulate in patient’s glomerular mesangial area, they will damage patient’s glomerular filtration membrane, which can increase its permeability. Then the protein in patient’s blood will leak out through patient’s urine, and that is why patient will have obvious symptoms of nephrotic syndrome.

Does every one with IgA nephropathy have ESRD?

IgA is a chronic kidney disease, and it can not be reversed. What’s more, the leaking protein can aggravate patient’s kidney damage obviously if it has not been well controlled, but patients with IgA nephropathy can get nephropathy nephrotic syndrome easily, which can cause patient to have severe proteinuria.

On the other hand, chronic kidney disease will progress slowly, and it needs many years before it progresses into the end stage. In fact, if patient is in the early stage of IgA nephropathy, which means patient’s condition is mild, his disease is able to be controlled. Besides, the modern treatments to proteinuria are effective. So if patient can protect himself well in his life, his disease may not progress into the end stage.

In the end, if you have any other trouble in dealing with IgA nephropathy, you can contact our online experts, and we are glad to help you.

  • Tag: IgA Nephropathy Basics
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