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How does IgA Nephropathy Affect Human Immune System

How does IgA Nephropathy Affect Human Immune SystemIgA nephropathy is an autoimmune kidney disease, which is caused by the accumulation of IgA in glomerular mesangium. This disease is caused by patient’s immune disorder, and it can affect patient’s immunity in turn. While how does IgA nephropathy affect human immune system?

How is IgA nephropathy caused?

Patient with IgA nephropathy will have abnormal level of IgA in his body, which means patient has immune disorder. And that may cause the accumulation of IgA immune complex in kidney, and then patient will have IgA nephropathy.

How does IgA nephropathy affect patient’s immune system?


A common symptom in patient with IgA is proteinuria, and IgA nephropathy often causes patient to have nephrotic syndrome, which can lead to large amount of protein loss.

While protein is an important part for our immunity. For example, antibody mainly consists of protein. For patients who have nephrotic syndrome, he often have low immunity, and patient can get infected easily. Thereby, the large loss of protein is very harmful to patient’s immunity.

Toxins accumulation

IgA nephropathy can damage patient’s kidney function greatly, and as the progression of patient’s disease, lots of toxins and wastes will accumulate in patient’s blood. Then patient’s immunity will resist these substances’ harm to body, which will consume patient’s immunity continuously. Besides, some toxins and wastes will also damage patient’s immune system.

These are the major measures that IgA nephropathy affects patient’s immunity directly. As we know, kidney is the organ that can regulate our body’s internal balance, so its damage can cause many systems’ disorder, and that will surely affect patient’s immune system.

  • Tag: IgA Nephropathy Basics
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